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Allopurinol reduces or prevents uric acid build-up, such as in gout and some kidney stones. Do not change routine treatment without medical advice, but follow the urgent rash instructions below.
What is the rash warning?
Stop allopurinol and contact a doctor immediately if you develop any new rash or skin reaction. Severe reactions can involve blistering or peeling skin, mouth sores or flu-like symptoms. Get emergency care for a severe rash or difficulty breathing.
What are the other side effects?
Nausea and vomiting can occur. Tell a doctor straight away about yellow skin or eyes, fever with a sore throat, unexplained bruising, or unusual thirst and frequent urination.
Who should talk to a doctor first?
Talk to your doctor if you are of Han Chinese, Thai, Korean, African or Indian origin, have liver, kidney, heart or thyroid problems, are having a gout attack, or are pregnant or breastfeeding.
Can it interact with other medicines?
Yes, including azathioprine, 6-mercaptopurine, warfarin, ciclosporin, phenytoin, theophylline, ACE inhibitors and diuretics.
Doses vary, so follow your prescriber, pharmacist and the medicine label. In Australia, call 000 in an emergency, or the Poisons Information Centre on 13 11 26 for a possible overdose. Outside Australia, use your local emergency and poison-information services.
Source: NHS: Allopurinol and UK patient leaflet: Allopurinol. General education does not replace individual medical advice. Updated November 2026.
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