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Fluoxetine is a prescription SSRI antidepressant used for depression, obsessive compulsive disorder and bulimia.
What should I know about Fluoxetine?
It raises serotonin levels, and it can take several weeks to work. Do not stop suddenly, as this can cause withdrawal symptoms. Your doctor will reduce the dose gradually.
What are the side effects?
Headache, nausea, diarrhoea or constipation, sleep problems, dizziness, low sex drive and weight changes can occur. Some ease after a couple of weeks.
Who should check first?
Tell your doctor if you have diabetes, epilepsy, heart disease, glaucoma, a bleeding disorder or a history of mania, or if you are pregnant or breastfeeding. Interactions include MAOIs, warfarin, NSAIDs, tamoxifen and St John’s wort.
When should I get help?
Seek urgent help for fast heartbeat with sweating, shaking and confusion, unexplained bruising or bleeding, or very low mood. If you have thoughts of harming yourself, seek urgent professional help. If you may act on them or have seriously harmed yourself, call your local emergency services immediately. Call your local emergency number (000 in Australia) for swelling of the throat or tongue, or trouble breathing.
Doses vary, so follow your prescriber, pharmacist and the medicine label. In Australia, call 000 in an emergency. Outside Australia, use your local emergency number.
Source: NHS: About fluoxetine. General education does not replace individual medical advice. Updated November 2026.
Explore our health guides and medicine FAQs. Medicine availability and product instructions vary by country; follow the leaflet supplied with your medicine.