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Fluconazole is an antifungal medicine used for Candida infections, including vaginal and oral thrush, and for some serious fungal infections.
What are the common side effects?
Headache, diarrhoea, nausea, stomach discomfort and rash can occur. Some people feel dizzy; do not drive while affected.
Is it safe in pregnancy?
Fluconazole is not usually recommended during pregnancy, but a clinician may use it when benefits outweigh risks. Ask your doctor or pharmacist before taking it if you are pregnant, planning pregnancy or breastfeeding.
Who should check first?
Check with your doctor if you have liver, kidney or heart problems, or low potassium. Tell them about any previous reaction to fluconazole or another antifungal.
Can it interact with other medicines?
Yes, with many. Examples include warfarin, statins, some antidepressants and antibiotics such as erythromycin or rifampicin. Ask your pharmacist to check your full list, including herbal products.
When should I get help?
Seek urgent help for trouble breathing, swelling of the face or throat, or blistering or peeling skin. Contact your doctor promptly for yellow skin or eyes, dark urine, pale stools, upper right stomach pain, or unusual tiredness.
Doses and formulations vary. Follow your prescriber, pharmacist and the leaflet supplied with your exact medicine. In Australia, call 000 for a medical emergency or the Poisons Information Centre on 13 11 26 for suspected poisoning or overdose. Outside Australia, use your local emergency and poison-information services.
Source: NHS: Fluconazole. General education does not replace individual medical advice. Updated November 2026.
Read more in our Health Guides. For website or catalogue questions, contact support; urgent medical concerns need a healthcare service.