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Lamotrigine: Uses, Side Effects and Precautions

Lamotrigine is a prescription medicine for epilepsy seizures, and for low mood in people with bipolar disorder.

What should I know about Lamotrigine?

If you are told to stop, the dose is usually reduced gradually. Keep taking it for as long as your doctor advises.

What are the side effects?

Headache, rash, nausea, dizziness, drowsiness, dry mouth and sleep problems can occur. Do not drive if you feel dizzy or drowsy.

Who should check first?

Tell your doctor if you have liver, kidney or heart conditions, or if you are planning pregnancy. Interactions include other epilepsy medicines, rifampicin, some HIV medicines and hormonal contraceptives.

When should I get help?

Get urgent advice for any new rash, blistering or peeling skin, yellow skin or eyes, or unusual bruising. If you have thoughts of harming yourself, seek urgent professional help. If you may act on them or have seriously harmed yourself, call your local emergency services immediately. Call your local emergency number (000 in Australia) for swelling of the throat or tongue, or trouble breathing.

Doses vary, so follow your prescriber, pharmacist and the medicine label. In Australia, call 000 in an emergency. Outside Australia, use your local emergency number.

Source: NHS: About lamotrigine. General education does not replace individual medical advice. Updated November 2026.

Explore our health guides and medicine FAQs. Medicine availability and product instructions vary by country; follow the leaflet supplied with your medicine.

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